Vegas Stakes is a handheld version of the console version and the sequel to Vegas Dream for the NES. The player starts out with $1,000 and can chose from a plethora of games like slot machines, blackjack, poker, craps and roulette.

There are four different casinos to choose from, unlocked by the players winnings, each with their own different betting structures and odds of winning. Players can meet people through these casinos and can make side bets through these people like horse races and boxing matches. Other events can occur as well, such as a parent asking for a donation to help pay for a child operation, the player makes the decision to contribute or ignore.