Lady Deathstrike discovers plans which allow her to build a weapon that will melt the adamantium skeleton that protects Logan (also known as Wolverine), a member of the noble mutant organization of X-Men. When this so-called destabilizer ray is completed, Lady Deathstrike and her fellow mutants Cyber and Sabretooth fully intend to use it, depriving the X-Men of their most powerful fighter. Wolverine has no choice but do whatever it takes to stop her from achieving this goal.

Wolverine goes alone in this action platform title, where the player takes control of the most famous of the X-Men, who hacks and slashes his way through twenty levels of enemies and bosses. There are four main activities which Wolvie can perform: hack and slash with his claws (the main attack); jump (very important to get through levels); heal (if he stays still, he will heal a little at a time; however, each level has a limited amount of time to complete, so standing around too much can be lethal); and enter the rage mode. If the player presses the attack button several times in a row, Wolvie will go off in a rage. Although hard to control in this state, his attack range improves. He also loses a little health every time.