When Sanrio Town is invaded by the evil King Block and his minions, only one skating kitten can save the day! Hello Kitty must battle the villainous block troops that have kidnapped Hello Kitty's friends and family.

Hello Kitty: Roller Rescue is an action platform game where the player controls Hello Kitty and battle through various captured levels of Sanrio Town. The player also gets the option of a computer-controlled partner to help battle the villains. Partners include My Melody, Purrin, and Monkichi. Each partner has their own special attack or ability that can help Hello Kitty out.

As they progress through the game, players can unlock movie clips and music from the game. They can also unlock character bios on various characters in the Hello Kitty Universe, as well as different outfits for Hello Kitty to wear and new weapons for her to use.